FOXO4
FOXO4 (FOXO4-DRI) is a D-amino acid retro-inverso peptide engineered to replicate the FOXO4 interaction domain that sequesters p53 within senescent cells. Competitive displacement of the endogenous FOXO4-p53 complex selectively triggers apoptosis in p21-high senescent cells in preclinical culture models. The retro-inverso design confers protease resistance; selectivity for senescent over proliferating cells is the mechanistic specification driving its use in cellular senescence research. For laboratory research use only.
- CAS
- 2460055-10-9
- MW
- 5358.06 g/mol
- Formula
- C228H388N86O64
- Purity
- >=99.0 HPLC
- Storage
- -20 °C, lyophilized
What is FOXO4?
FOXO4 is a synthetic research compound studied in laboratory settings. It has molecular formula C228H388N86O64, a molecular weight of 5358.06 g/mol, CAS 2460055-10-9. It is intended for in vitro research use only and is not for human or animal use.
What purity is AminoZone's FOXO4?
AminoZone supplies FOXO4 at >=99.0% purity, verified by third-party HPLC analysis. A certificate of analysis is available on request.
How is FOXO4 supplied?
FOXO4 is supplied as a lyophilized powder in sealed research-grade vials, stored -20 °C, lyophilized, intended for in vitro and laboratory research use only.